Sky Journal of Microbiology Research Vol. 4(4), pp. 031-041, June, 2016. Available online, http://www.skyjournals.org/SJMR
ISSN 2315-876X ©2016 Sky Journals

 

Full Length Research Paper

Synthesis, characterization and antimicrobial screening of some novel coumarin-pyrazolo Schiff bases

Shipra Baluja1*, Sumitra Chanda2, Pooja Moteriya3 and Rahul Talaviya1

 

1Department of Chemistry, Saurashtra University, Rajkot-360005 (Gujarat), India.
2Department of Bioscience, Saurashtra University, Rajkot-360005 (Gujarat), India.

 

*Corresponding author. E-mail: shipra_baluja@rediffmail.com.   

 

Accepted 17 May, 2016

 

Abstract

Some novel coumarin-pyrazolo substituted Schiff bases were synthesized by two different methods; conventional and microwave irradiation from coumarin-pyrazole aldehyde and different substituted aryl amines. The structure conformation of these synthesized compounds was done by FT-IR, 1H NMR, 13C NMR and mass spectral data. All these synthesized compounds were also tested for in-vitro antimicrobial activity against some bacterial as well as fungal strains in DMF and DMSO. It is observed that some of Schiff bases showed excellent antibacterial activity in both solvents.

 

Key words: Schiff bases, gram positive bacteria, gram negative bacteria, DMF, DMSO.

 

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