Sky Journal of Microbiology Research Vol. 4(6), pp. 052-059, August, 2016. Available online, http://www.skyjournals.org/SJMR
ISSN 2315-876X ©2016 Sky Journals

 

Full Length Research Paper

Serostatus of cytomegalovirus among population, Jazan region, Saudi Arabia 

Marwah Bakri1, Ahmed Agag1, Abdulrahman Alnemri2, Yahya Hobani1, Abdullah Najmi3, Abdullah I. Alaamri1 and Zaki Eisa4

 

1Jazan University, Jazan, Saudi Arabia.
2King Saud University, Riyadh, Saudi Arabia.
3King Fahd Hospital, Jazan, Saudi Arabia.
4Head Of Virology, King Fahd Hospital, Jazan, Saudi Arabia.

 

*Corresponding author. E-mail: *Corresponding author. E-mail: Zaki67@hotmail.com.  Tel.: +966505767094.

 

Accepted 22 August, 2016

 

Abstract

A high prevalence of Cytomegalovirus (CMV) was detected to be spreading fast in the Jazan region in Saudi Arabia. CMV has the ability to remain latent within the body over a long period. CMV is a life-threatening infection to the immunocompromised persons, such as organ and bone marrow transplant recipients and cancer patients. It can cause a wide spectrum of infections in immunocompetent hosts as; hepatitis, colitis, and encephalitis. It is the most common cause of congenital infection. It can cause intrauterine growth retardation, microcephaly, retinitis and hearing defects. CMV is found throughout all geographical locations, but it is more widespread in developing countries. The main objective of the study is to assess the prevalence of CMV in Jazan region, Saudi Arabia. A total of 486 (315 non-pregnant females, 87 pregnant females and 48 males) random serum samples were collected. The samples were screened for anti-CMV IgM and IgG antibodies using the enzyme-linked immunosorbent assay (ELISA). CMV IgG antibody was positive in 64.28% of males and 78.35% in females. CMV IgM antibody was positive in 25% of males and in 3.73% of females. Prevalence of CMV in all age groups was generally high but in older age reached 100% in both male and female. Positive seroprevalence of the CMV antibody in the randomly selected representative sample was 83.3%, 75% of the seropositive female were pregnant in age at 20 - 40 year and seropositivity among pregnant women was 93.10% and non-pregnant women were 79.05%. The high prevalence of CMV is an indication that the virus is spreading fast in the Jazan region and it is a warning sign to anticipate its serious complications. Accordingly, it is recommended to set up appropriate plans and preventive measures by decision makers of health authorities to reduce the spread of the virus and to raise the public awareness of the disease among the population in the Jazan region.

 

Key words: Cytomegalovirus, antibodies, seroprevalence, population.

 

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