Sky Journal of Medicines and Medical Sciences Vol. 5(1), pp. 001-007, March, 2017, Available online, http://www.skyjournals.org/SJMMS

ISSN 2315-8808 ©2017 Sky Journals

 

Full Length Research Paper

Bladder tumour antigen seropositivity levels in human immunodeficiency virus seropositive subjects and HIV subjects co-infected with Mycobacterium tuberculosis in Nnewi Nigeria
 

Manafa P. O.1, Chukwuma G. O.1, Akpuogwu U. A.1, Chukwuma O. M.1, Ibe N. C.1, Nwene E. K.2, Akulue J. C1, Aneke J. C.3 , Manafa V.I.1, Onyenekwe C. C.1

 

1Department of Medical Laboratory Science, Faculty of Health Sciences & Technology, Nnamdi Azikiwe University, Nnewi Campus.
2Initiative for good health in Nigeria.
3Department of Haematology, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria.
 

*Corresponding author. E-mail:  georgechuma@yahoo.com.  Tel.:+2348034101608.
 

Accepted  8 February, 2017

 

Abstract

 

Patients with chronic HIV infection may develop diseases such as tuberculosis and bladder cancer, associated with long-term exposure to several oncogenic risk factors. This study evaluated the levels of bladder tumour antigen seropositivity in HIV seropositive individuals and HIV seropositive subjects co-infected with tuberculosis. A total of 50 subjects were recruited. These include; 17 HIV seropositive subjects, 17 HIV seropositive subjects co-infected with tuberculosis, 16 apparently healthy individuals (control group). Bladder tumor antigen levels were estimated by the Enzyme Linked Immunosorbent Assay technique. The mean serum levels of bladder tumor antigen were significantly increased in HIV seropositive subjects and HIV seropositive subjects co-infected with tuberculosis compared with the control (P < 0.05). Similarly, there was a significant increase in mean serum levels of bladder tumour antigen in HIV seropositive males and HIV seropositive males co-infected with tuberculosis, compared with HIV seropositive females and HIV seropositive females co-infected with tuberculosis, respectively (P < 0.05). There existed no significant increase in the mean serum levels of bladder tumour antigen in HIV seropositive subjects co-infected with tuberculosis compared with HIV seropositive subjects without TB (p > 0.05). There is a need to explore further, the prognostic potentials of bladder tumour antigen in HIV and Tuberculosis infections.

Key words: HIV, bladder, tumour, antigen, tuberculosis.

 

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