Sky Journal of Biochemistry Research Vol. 5(3), pp. 014-017, July, 2016.  Available online http://www.skyjournals.org/SJBR

ISSN 2315-8786 ©2016 Sky Journals

 

Full Length Research Paper

Determination of dissociation constant of some pyrimidine derivatives
 

Shipra Baluja*, Kajal Nandha and Paras Ramavat

 

Physical Chemistry Laboratory, Department of Chemistry, Saurashtra University, Rajkot-360005 (Gujarat), India.

 

*Corresponding author. E-mail: shipra_baluja@rediffmail.com.

 

Accepted 29 April, 2016

 

Abstract

 

Some new pyrimidine derivatives have been synthesized and their structures have been confirmed by IR, 1H NMR and mass spectral data. The thermodynamic dissociation constants of pyrimidine derivatives were studied in 1, 4-dioxane: water (50:50 v/v) solvent systems at different temperatures ranging from 25°C to 45°C at 10°C interval using Calvin–Bjerrum pH titration method. Further, some thermodynamic parameters such as enthalpy (ΔH), Gibb’s free energy (ΔG) and entropy (ΔS) of solutions have also been evaluated at different temperatures for these systems.

 

Key words: Acidity constant, pyrimidine, 1, 4-dioxane, enthalpy, Gibb’s free energy, entropy.

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Ramavat P
 
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